This category examines antidepressant pharmacotherapy for major depressive disorder, generalized anxiety, PTSD, and related mood conditions. Coverage includes selective serotonin reuptake inhibitors, SNRIs, tricyclics, and atypical agents, with attention to mechanism of action, therapeutic dosing, and titration protocols. Articles address common adverse effects, drug interactions, black-box warnings, and discontinuation syndrome. Readers will find guidance on selecting an appropriate agent based on symptom profile, comorbidities, and patient history. Special populations, including adolescents, pregnant patients, and older adults, receive dedicated clinical consideration throughout.