Rabies is a fatal viral infection spread through the saliva of infected mammals such as dogs, bats, and raccoons. The lyssavirus travels along peripheral nerves toward the brain, making rapid medical intervention after a bite or scratch essential. Early warning signs include fever, tingling at the wound site, and progressive neurological deterioration such as confusion and hydrophobia. Post-exposure prophylaxis, consisting of rabies immunoglobulin and a vaccine series, is nearly 100% effective when administered before symptoms develop. Once clinical signs appear, the disease is almost universally fatal, underscoring the importance of immediate wound cleaning and urgent medical evaluation after any suspected animal exposure.