The Cost Breztri of with Medicare
Breztri can run $400 or more without insurance, but Medicare plans may cover inhaler medications for COPD, including Breztri. Coverage and out-of-pocket costs differ depending on the particulars of your plan.

Breztri Aerosphere (budesonide, glycopyrrolate, and formoterol fumarate) is a metered-dose inhaler intended for adults who have chronic obstructive pulmonary disease (COPD).
Medicare may help pay for Breztri for COPD, but you’ll need to verify your plan’s details because there is no universal mandate for inhaler coverage . Each Medicare Part D or Medicare Advantage Prescription Drug (MAPD) plan can include different medications on its formulary.
Also note: if you require a nebulizer rather than an inhaler, coverage is generally provided under Medicare Part B.
How much does Breztri cost with Medicare?
Without insurance, a 5.9-gram (g) Breztri inhaler is roughly $400, while a 10.7-g inhaler can be about $700.
Whether your Medicare drug plan pays for a Breztri inhaler depends on its formulary, the list of covered drugs that varies by plan. If your plan does not include this inhaler, it may cover a different inhaler instead.
When Breztri is covered, your share of the cost depends on the formulary tier it’s placed in. Drugs in higher tiers typically cost more to you. Beginning in 2025, you’ll be limited to no more than $2,000 per year in out-of-pocket drug costs under Medicare plans.

Keep in mind that Part D and MAPD plans are offered by private insurers, so deductibles, premiums, and copays differ by plan. For 2025, the national base beneficiary premium for Part D is $36.78, and the Centers for Medicare & Medicaid Services (CMS) reports the average monthly premium for Medicare Advantage plans is about $17 .
If you use a nebulizer and are covered under Part B, you typically pay 20% of the Medicare-approved amount after meeting your annual deductible of $257 , while maintaining your monthly premium of $185.
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How can I get cheaper Breztri with Medicare?
Often, the most affordable option through your Medicare plan is a generic equivalent, which usually appears in lower formulary tiers and costs less out of pocket.

There is no generic for Breztri, but alternative medications may provide similar benefit at a lower price and could be covered by your plan.
Because Breztri is costly, some plans may require prior authorization before they approve coverage. They may also implement step therapy, asking you to try a less expensive, equally effective medication first.
AstraZeneca, the maker of Breztri, runs a financial assistance program that might reduce costs for eligible patients, including some on Medicare. Check the manufacturer’s website for eligibility details.
Takeaway
Breztri is a brand-name inhaler formulated for long-term management of chronic obstructive pulmonary disease (COPD) in adults. While Medicare drug plans can cover COPD inhalers like Breztri, there is no uniform coverage requirement, so whether and how much you pay depends on the specific drug and your plan.
Typically, drug coverage comes from Medicare Part D or a Medicare Advantage Prescription Drug (MAPD) plan, which may include covered inhalers. If the medication must be delivered via nebulizer, coverage generally falls under Part B.
Frequently Asked Questions
Medicare may cover Breztri through Part D or Medicare Advantage Prescription Drug plans, but coverage depends on each plan’s formulary and is not guaranteed across all plans.
Your out-of-pocket cost depends on your plan’s formulary tier, deductible, and copay structure; costs can range from relatively low copays to several hundred dollars if not covered.
Breztri, as an inhaler, is typically covered under Part D or Medicare Advantage drug benefits; nebulizer-delivered medications are more likely covered under Part B.
Options include selecting a plan with favorable formulary placement, seeking a covered alternative or generic if appropriate, using manufacturer assistance programs, or requesting prior authorization or formulary exceptions.
Yes—starting in 2025, Medicare plans will limit out-of-pocket drug costs (e.g., a $2,000 cap was noted), which could reduce maximum annual spending on costly drugs like Breztri depending on plan application.
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