Aloe vera is commonly used as a topical gel for soothing sunburns, but its antioxidant-rich nature suggests it might offer additional health advantages. Research indicates it could support skin, dental and oral, digestive health, and possibly help with blood sugar regulation.
The aloe vera plant is a succulent belonging to the genus Aloe. It thrives in warm climates and has a long history of medicinal use.
Aloe vera juice is a viscous liquid derived from the inner flesh of aloe leaves. Historically, people have used the plant both externally and internally.
This article reviews the evidence for potential health benefits when aloe vera is consumed as a juice or taken in other forms.
1. Contains antioxidants
Laboratory studies suggest aloe has anti-inflammatory actions, which is why it’s frequently used to alleviate skin injuries such as burns and wounds.
These anti-inflammatory effects are believed to stem from polyphenols, a class of antioxidant-rich plant compounds.
Antioxidants protect tissues from damage caused by free radicals, commonly referred to as oxidative stress. Persistent oxidative stress has been linked to a higher risk of some diseases, including heart disease and certain cancers.
That said, there’s currently no conclusive research showing that aloe vera juice directly reduces the risk of these conditions.
SummaryAloe vera juice contains polyphenols, which provide antioxidant activity. Antioxidants are associated with health benefits, but specific human studies tying aloe’s antioxidants to disease prevention are limited.
2. May help treat skin conditions and enhance skin appearance
Aloe vera’s anti-inflammatory qualities make it a candidate for treating burns and skin disorders such as atopic dermatitis.
Most evidence for skin benefits comes from topical use rather than ingestion, although a few studies have looked at oral aloe supplements.
One trial reported that taking 40 mcg of aloe sterol daily for 12 weeks improved skin elasticity in men under 46.
Another study found that consuming aloe correlated with increased collagen production and reduced wrinkle visibility in women over 40.
It’s important to note these trials used aloe supplements rather than aloe juice. While findings are encouraging, they are not definitive and require more human research.
SummaryApplying aloe vera topically is commonly thought to help with some skin issues. Some studies suggest oral aloe supplements may boost skin elasticity and lessen wrinkles, but further studies are necessary.
3. May aid in pre-diabetes management
Earlier studies suggested both aloe gel and juice might reduce fasting blood glucose in individuals with type 2 diabetes.
However, two reviews found that drinking aloe vera juice did not significantly improve fasting blood glucose in people with type 2 diabetes — though benefits were seen in those with pre-diabetes.
Another trial observed improvements in blood glucose and blood lipid profiles among people with pre-diabetes who drank aloe juice.
While these results are promising, research is limited. Larger, randomized, controlled trials are needed to verify any link between aloe vera juice and blood sugar control.
Additionally, aloe vera extract supplements are not standardized or regulated and should not be considered a safe replacement for medical diabetes treatments.
SummaryEarly research indicates aloe vera juice may lower fasting blood sugar in people with pre-diabetes. Still, stronger, more recent evidence is needed to confirm these effects.
4. May help with digestive issues
Aloe vera juice contains anthraquinone glycosides, plant compounds that can have laxative effects and might ease constipation. However, the evidence is dated and the safety of using aloe for constipation remains unclear.
In 2002, the U.S. Food and Drug Administration removed approval for aloe-based laxatives for over-the-counter sale because their safety and effectiveness had not been adequately established.
Some small studies suggest aloe syrup may reduce symptoms of gastroesophageal reflux disease (GERD), and early research indicates aloe extract could help with irritable bowel syndrome (IBS).
Overall, while aloe vera might offer digestive benefits, there isn’t enough reliable data on safe doses or long-term safety for these uses.
SummaryAloe vera juice may act as a laxative, but safety data on aloe products are limited. Some research points to other digestive benefits, yet more rigorous studies are required.
5. May support dental and oral health
Animal studies indicate aloe vera possesses antibacterial properties and might aid treatment of some dental and oral conditions.
In one trial of 74 people with oral submucous fibrosis — a chronic, painful inflammatory condition of the mouth — taking 1 ounce (30 mL) of aloe vera juice twice daily for 3 months matched the effectiveness of conventional treatments such as hydrocortisone injections.
Another study reported that an aloe vera mouthwash reduced the severity and pain of oral mucositis, a frequent side effect of chemotherapy and radiation, in patients with head and neck cancers.
Further, a trial involving 64 cancer patients found that using an aloe vera mouthwash three times daily for 14 days decreased the incidence and pain of chemotherapy-induced stomatitis.
It’s also been proposed that aloe mouthwash could help lower dental plaque and manage pain and swelling after oral surgery (19, ).
Although longer-term studies are needed, these findings suggest aloe vera formulations might offer alternative approaches for certain oral and dental issues.
SummaryAloe vera juice and mouthwash may benefit various dental and oral conditions due to potential antibacterial effects. More comprehensive research is still necessary.
Aloe vera juice considerations
Aloe is available as a juice or a gel. The juice is the sap derived from the plant’s outer leaf layers, while the gel is a thick substance from the inner leaf tissue.
Typically, aloe juice is taken orally and the gel is used externally.
Some studies suggest benefits from aloe juice and supplements for various conditions, but most evidence comes from small, short-term trials, and larger clinical studies in humans are required.
Consult a healthcare professional before introducing aloe vera juice or supplements into your routine, particularly when it concerns health or diet changes.
This is particularly important if you are pregnant, breastfeeding, or chestfeeding, as the safety of aloe products in these populations is unclear.
Also review any aloe supplements or juices with your doctor if you take medications to avoid potential interactions.
The bottom line
Aloe vera is best known as a topical gel for sunburn relief, but it may offer additional health benefits due to its antioxidant content.
Preliminary research suggests aloe vera might aid skin, dental, oral, and digestive health and could help with blood sugar control in some cases. However, more long-term human trials are necessary to confirm these potential benefits.
Always speak with a healthcare provider before trying aloe vera products, especially if you are pregnant, nursing, or taking medications.
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