Salicylic Acid vs. Benzoyl Peroxide: Which Is Better for Acne?

Salicylic acid and benzoyl peroxide each help clear different forms of acne and reduce the chance of future breakouts. However, they shouldn’t be applied to the same patch of skin at the same time.

These two compounds are among the most recognized acne-fighting agents available without a prescription. Both can help treat mild acne and lower the frequency of new blemishes when used appropriately.

Read on to understand the advantages and possible adverse effects of each ingredient and guidance on how to use them safely.

What does each ingredient do?

Both agents aid in shedding dead skin cells, which can plug pores and trigger acne flare-ups.

Salicylic acid

Salicylic acid is particularly effective for treating blackheads and whiteheads. With consistent use, it can also help stop new comedones from forming.

Benzoyl peroxide

Benzoyl peroxide is a common over-the-counter acne treatment best suited for classic red, pus-filled pimples (pustules).

Besides sloughing away excess oil and dead skin, benzoyl peroxide works to kill bacteria that contribute to acne beneath the skin’s surface.

What side effects can occur?

Although side effects differ between the two, both ingredients are generally considered safe overall. They’re also thought to be safe during pregnancy. People who are allergic to aspirin should avoid salicylic acid.

Both products can cause dryness and irritation, especially when you first begin using them. Allergic reactions are possible, though uncommon. Seek emergency medical care if you experience severe swelling or difficulty breathing.

Salicylic acid

Salicylic acid reduces excess sebum in pores, but it can sometimes strip too much oil and leave skin unusually dry.

Other potential side effects include:

• hives
• itchiness
• peeling
• stinging or a tingling sensation

Benzoyl peroxide

Benzoyl peroxide can be harsher on sensitive skin. It tends to be more drying than salicylic acid and may cause stronger irritation.

If you have any of the following conditions, consult a healthcare provider before using benzoyl peroxide:

• eczema
• seborrheic dermatitis
• psoriasis

This ingredient can also bleach clothing and hair, so use cautiously and wash your hands well after application.

How to choose the right product

Your choice depends on:

• Type of acne: Salicylic acid is better for blackheads and whiteheads, while benzoyl peroxide targets mild pustules more effectively.
• Severity of breakouts: Both are aimed at mild acne and may take several weeks to show full benefits. Benzoyl peroxide might offer quicker relief as a spot treatment.
• Activity level: If you’re active and sweat during the day, benzoyl peroxide can transfer to and stain clothing. You might prefer using it at night or choosing salicylic acid instead.
• Skin sensitivity: Salicylic acid is generally gentler and may be less likely to irritate sensitive skin than benzoyl peroxide.
• Underlying health issues: Although available over the counter, these ingredients aren’t automatically safe for everyone. Check with a clinician if you have an existing skin disorder or conditions such as kidney disease, diabetes, or liver disease.

»Learn more:Can retinol be used to treat acne?

How to use them

Do not use a salicylic acid- or benzoyl peroxide-containing product at every step of your skincare routine. For instance, if you use a salicylic acid cleanser, avoid also using it in your toner or moisturizer.

Layering the same active ingredient through multiple steps can over-dry your skin and potentially worsen acne.

Also be diligent about daily sunscreen and avoid tanning. While these acne treatments don’t cause sun sensitivity to the same degree as retinoids or alpha-hydroxy acids, unprotected sun exposure can aggravate acne and raise the risk of scarring and skin cancer.

»Try:Best sunscreens in 2025

Salicylic acid

Over-the-counter formulations—gels, creams, cleansers, astringents, and similar products—typically contain salicylic acid in concentrations from about 0.5% to 7%.

Salicylic acid can be applied morning and night and is mild enough to be used as an occasional midday spot treatment.

Benzoyl peroxide

Benzoyl peroxide products are sold in several over-the-counter strengths.

Start with a lower concentration to reduce dryness and irritation. For instance, begin with 2.5% and consider moving to 5% if you see little improvement after about six weeks.

You might start with a gentle cleanser containing benzoyl peroxide and progress to a gel as your skin adapts. If there’s no benefit after six weeks, increasing to 10% is an option.

Benzoyl peroxide can be used up to twice daily. After cleansing and toning, apply a thin layer over the entire affected area and allow it to dry for a few seconds before moisturizing.

If you’re new to benzoyl peroxide, begin with a single daily application and gradually increase to morning and evening as tolerated. Some individuals with sensitive skin find every other day use works best.

If you use a retinoid or retinol at night, reserve benzoyl peroxide for morning use to minimize irritation and other side effects.

Can you use both at once?

Your regimen might include both salicylic acid and benzoyl peroxide, but you should avoid applying both to the same area of skin — even at different times of the day — because that raises the likelihood of excessive dryness, irritation, and peeling.

A safer strategy is to use each ingredient for specific acne types. For instance, use salicylic acid as an overall preventive treatment and apply benzoyl peroxide as a targeted spot treatment for inflamed pimples.

Takeaway

Although acne doesn’t have a definitive cure, salicylic acid and benzoyl peroxide can help reduce and clear many breakouts.

If you don’t notice improvement after about six weeks, consult a dermatologist. They may suggest stronger options like retinoids or prescription-strength treatments.